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Displaying drugs 1 - 25 of 40 in total
Avapritinib
Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the treatment of multidrug resistant cancers. Avapritinib shares a...
Approved
Investigational
Tirbanibulin
Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand name Klisyri. Actinic keratosis is a chronic condition characterized...
Approved
Investigational
Dostarlimab
Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Atezolizumab
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Paclitaxel
Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as...
Approved
Vet approved
Matched Synonyms: … NAB-PACLITAXEL COMPONENT PACLITAXEL ... Paclitaxel ... ABI-007 COMPONENT PACLITAXEL …
Matched Name: … Paclitaxel …
Matched Description: … Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. ... Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in ... 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel …
Matched Categories: … paclitaxel ... paclitaxel and encequidar …
Matched Products: … Paclitaxel Paclitaxel ... Paclitaxel ... Paclitaxel NP …
Matched Name: … Paclitaxel …
Matched Description: … Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. ... Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in ... 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel …
Matched Categories: … paclitaxel ... paclitaxel and encequidar …
Matched Products: … Paclitaxel Paclitaxel ... Paclitaxel ... Paclitaxel NP …
Cangrelor
Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion...
Approved
Trastuzumab
Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Bovine type I collagen
Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues. It plays a vital role in cell growth, differentiation, attachment, and migration . Often combined with other ingredients, such as fibroblasts and keratinocytes, it allows for accelerated and effective wound healing...
Approved
Matched Description: … Interestingly, bovine type I collagen has been studied as a possible endovascular stent material, and …
Cabazitaxel
Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more readily penetrate the blood–brain barrier compared to...
Approved
Matched Description: … pump, cabazitaxel can more readily penetrate the blood–brain barrier compared to other taxanes like [paclitaxel …
Gemcitabine
Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose. As a prodrug, gemcitabine is transformed...
Approved
Matched Description: … advanced ovarian cancer in combination with [carboplatin], metastatic breast cancer in combination with [paclitaxel …
Ramucirumab
Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, permeability,...
Approved
Investigational
Matched Description: … advanced gastric or gastro-esophageal junction adenocarcinoma as a single agent or in combination with paclitaxel …
Docetaxel
Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... [A259676] Compared to paclitaxel, docetaxel is two times more potent as an inhibitor of microtubule depolymerization …
Pemirolast
Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic...
Approved
Investigational
Matched Description: … Pemirolast is potentially useful for prophylaxis of pulmonary hypersensitivity reactions to drugs such as paclitaxel …
Celecoxib
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Pembrolizumab
Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes...
Approved
Paclitaxel poliglumex
Experimental
Investigational
Matched Synonyms: … Paclitaxel poliglumex …
Matched Name: … Paclitaxel poliglumex …
Matched Categories: … paclitaxel poliglumex …
Matched Name: … Paclitaxel poliglumex …
Matched Categories: … paclitaxel poliglumex …
Paclitaxel ceribate
Investigational
Matched Synonyms: … Paclitaxel ceribate …
Matched Name: … Paclitaxel ceribate …
Matched Name: … Paclitaxel ceribate …
Paclitaxel trevatide
Three paclitaxel molecules linked by a cleavable succinyl ester linkage to a brain peptide vector, Angiopep-2, conjugate named ANG1005.
Investigational
Matched Synonyms: … Paclitaxel trevatide ... [a-N-(2'succinyl-paclitaxel)Thr]-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-[epsilon-N-(2'succinyl-paclitaxel)Lys ... ]-Arg-Asn-Asn-Phe-[epsilon-N-(2'succinyl-paclitaxel)Lys]-Thr-Glu-Glu-Tyr …
Matched Name: … Paclitaxel trevatide …
Matched Description: … Three paclitaxel molecules linked by a cleavable succinyl ester linkage to a brain peptide vector, Angiopep …
Matched Name: … Paclitaxel trevatide …
Matched Description: … Three paclitaxel molecules linked by a cleavable succinyl ester linkage to a brain peptide vector, Angiopep …
Paclitaxel docosahexaenoic acid
A combination of docosahexaenoic Acid (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.
Investigational
Matched Synonyms: … DHA Paclitaxel ... DHA-paclitaxel ... PACLITAXEL-DHA …
Matched Name: … Paclitaxel docosahexaenoic acid …
Matched Description: … A combination of [docosahexaenoic Acid] (a natural fatty acid) and [paclitaxel] (an anticancer drug) …
Matched Name: … Paclitaxel docosahexaenoic acid …
Matched Description: … A combination of [docosahexaenoic Acid] (a natural fatty acid) and [paclitaxel] (an anticancer drug) …
Naftopidil
Naftopidil has been investigated for the treatment of Disorder of Urinary Stent.
Investigational
Matched Description: … Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. …
Necuparanib
Necuparanib is under investigation in clinical trial NCT01621243 (M402 in Combination With Nab-paclitaxel and Gemcitabine in Pancreatic Cancer).
Investigational
Matched Description: … Necuparanib is under investigation in clinical trial NCT01621243 (M402 in Combination With Nab-paclitaxel …
Eftilagimod alfa
Eftilagimod alfa is under investigation in clinical trial NCT02614833 (IMP321 (Eftilagimod Alpha) as Adjunctive to a Standard Chemotherapy Paclitaxel Metastatic Breast Carcinoma).
Investigational
Matched Description: … in clinical trial NCT02614833 (IMP321 (Eftilagimod Alpha) as Adjunctive to a Standard Chemotherapy Paclitaxel …
Succinobucol
AGI-1067, is a novel small molecule with anti-oxidant and anti-inflammatory properties that was discovered by AtheroGenics and designed to treat atherosclerosis of the blood vessels of the heart, or coronary artery disease.
Investigational
ONT-093
ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
Investigational
Matched Description: … ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel …
AI-850
AI-850 is a Cremophor(R)-free formulation of paclitaxel, the active ingredient in Taxol(R), a product used to treat a variety of solid tumors.
Investigational
Matched Description: … AI-850 is a Cremophor(R)-free formulation of paclitaxel, the active ingredient in Taxol(R), a product …
Displaying drugs 1 - 25 of 40 in total